反応 #79200

反応方程式

2-amino-4-Cyano-N-(2-pyridyl)aniline

(E)-cinnamoyl chloride

(E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole

→

(E)-5-Cyano-1-(2-pyridyl)-2-styryl-1H-benzimidazole

反応条件

実験手順

(E)-5-Cyano-1-(2-pyridyl)-2-styryl-1H-benzimidazole was prepared from 2-amino-4-Cyano-N-(2-pyridyl)aniline and (E)-cinnamoyl chloride according to the preparation of (E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole (Example 1, method A). MW: 322.37; mp: 172.0-172.7° C.; 1H-NMR (CDCl3) δ: 8.80 (1H. ddd, J=4.8, 1.8, 0.7 Hz), 8.15-8.02 (2H, m), 8.05 (1H, d, J=16.0 Hz), 7.57-7.48 (6H, m), 7.42-7.33 (3H, m), 7.07 (1H, d, J=16.0 Hz).

出典