反応 #79195

反応方程式

2-nitro-N-(2-pyridyl)-4-trifluoromethylaniline

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titled compound

収率 85.0%

2-Amino-N-(2-pyridyl)-4-trifluoromethylaniline

収率 85.0%

溶媒

methanol

反応条件

後処理

1. 1
   ろ過The mixture was filtered through a pad of celite
2. 2
   濃縮the filtrate was concentrated to dryness

実験手順

A mixture of 2-nitro-N-(2-pyridyl)-4-trifluoromethylaniline (1.00 g, 3.5 mmol), 5% palladium on carbon (0.23 g) and methanol (50 ml) was stirred under a hydrogen atmosphere for 100 min. The mixture was filtered through a pad of celite and the filtrate was concentrated to dryness to give 0.75 g (85%) of the titled compound as yellow brown solids. 1H-NMR (CDCl3) δ: 8.19 (1H, ddd, J=5.1, 1.8, 0.7 Hz), 7.49 (1H, ddd, J=8.3, 7.0, 1.8 Hz), 7.35 (1H, d, J=7.7 Hz), 7.05-7.01 (2H, m), 6.76 (1H, ddd, J=7.0, 5.1, 1.1 Hz), 6.55 (1H, ddd, J=8.3, 1.1, 0.7 Hz), 6.31 (1H, br.s), 3.98 (2H, br.s).

出典