反応 #791579

反応方程式

hydrochloric acid

3-(4-methoxyphenyl)propionic acid

lithium aluminum hydride

water

→

3-(4-methoxyphenyl)propanol

溶媒

ether

ether

反応条件

後処理

1. 1
   workup.STIRRINGAfter stirring at room temperature for 30 minutes
2. 2
   温度the mixture was refluxed for 1 hours
3. 3
   温度After cooling
4. 4
   抽出extracted with ether
5. 5
   洗浄The organic layer was washed with saturated aqueous solution of sodium chloride
6. 6
   濃縮concentrated under reduced pressure

実験手順

A solution of the 3-(4-methoxyphenyl)propionic acid in 100 ml of anhydrous ether was added dropwise to a suspension of 1.10 g of lithium aluminum hydride in 50 ml of anhydrous ether with stirring at room temperature over 20 minutes. After stirring at room temperature for 30 minutes, the mixture was refluxed for 1 hours. After cooling, water was added with ice cooling, and the mixture was made acidic by further addition of 10% hydrochloric acid and then extracted with ether. The organic layer was washed with saturated aqueous solution of sodium chloride, driven over anhydrous magnesium sulfate and concentrated under reduced pressure to give 5.06 g of 3-(4-methoxyphenyl)propanol.

出典