反応 #79148

反応方程式

2-styryl-1H-benzimidazole

2-Chloro-3-Cyanopyridine

(E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole

hydrogen chloride

→

titled compound

3-Cyanopyridin-2-yl-2-styryl-1H-benzimidazole hydrochloride

溶媒

methanol

反応条件

後処理

1. 1
   濃縮concentrated to dryness
2. 2
   その他The residue was recrystallized from ethyl acetate

実験手順

Free base of the titled compound was prepared from 2-styryl-1H-benzimidazole and 2-Chloro-3-Cyanopyridine according to the preparation of (E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole (Example 1, method B). The free base was treated with a 10% methanol solution of hydrogen chloride and concentrated to dryness. The residue was recrystallized from ethyl acetate to give the titled compound. MW: 334.38; mp: 171.5-172.5° C.; 1H-NMR (CDCl3) δ: 8.98 (1H, dd, J=4.8, 1.8 Hz) 8.32 (1H, dd, J=7.7, 1.8 Hz), 7.98 (1H, d, J=16.1 Hz), 7.89-7.85 (1H, m), 7.67 (1H, dd, J=7.7, 4.8 Hz), 7.52-7.47 (2H, m), 7.42-7.26 (5H, m), 7.23-7.19 (1H, m), 6.83 (1H, d, J=16.1 Hz).

出典