反応 #78929

反応方程式

compound 2

Methanesulfonic acid 1-[1-(4-chloro-phenyl)-cyclobutanecarbonyl]-piperidin-3-ylmethyl ester

1-(2-trifluoromethoxyphenyl)piperazine

cesium carbonate

→

9

収率 32.3%

[1-(4-Chloro-phenyl)-cyclobutyl]-{3-[4-(2-trifluoromethoxy-phenyl)-piperazin-1-ylmethyl]-piperidin-1-yl}-methanone

収率 32.3%

反応条件

後処理

1. 1
   その他Compound 9 was prepared

実験手順

Compound 9 was prepared using the method described in Example 3, starting with compound 2 (1.0 g, 2.60 mmol), 1-(2-trifluoromethoxyphenyl)piperazine (0.70 g, 2.86 mmol), and cesium carbonate (1.27 g, 3.90 mmol) to give 9 (0.45 g, 32%); C28H33ClF3N3O 2, LRMS (m/z)=537 (MH+).

出典