反応 #78866

反応方程式

triethylamine

4-bromophenol

cinnamoyl chloride

→

3-phenylacrylic acid 4-bromophenyl ester

収率 99.8%

溶媒

dichloromethane

反応条件

後処理

1. 1
   洗浄was washed with water (250 ml), 1 M aqueous HCl
2. 2
   乾燥dried over anhydrous sodium sulphate
3. 3
   その他Evaporation in vacuum

実験手順

An ice-cooled solution of 4-bromophenol (69.2 g) and cinnamoyl chloride (66.8 g) in dichloromethane (150 ml) was treated with triethylamine (40.6 g). After stirring for 18 hrs at room temperature the mixture was washed with water (250 ml), 1 M aqueous HCl, and dried over anhydrous sodium sulphate. Evaporation in vacuum left solid 3-phenylacrylic acid 4-bromophenyl ester (121.0 g, 99.8% yield), m.p. 113.3° C., tlc: (1) 0.83. NMR (CDCl3): 116.85, 118.87, 123.49, 128.38, 129.06, 130.90, 132.49, 134.02, 147.07, 149.84, 165.06.

出典