反応 #78819

反応方程式

2-chloro-4-phenylamino-quinazoline

N-methyl-(4-aminophenyl)-methanesulfonamide

→

N-methyl-[4-(4-phenylamino-quinazolin-2-ylamino)-phenyl]-methanesulfonamide hydrochloride

溶媒

ethanol

isopentylalcohol

反応条件

後処理

1. 1
   その他The warm reaction mixture
2. 2
   その他the hydrochloride salt, which is crystallizing
3. 3
   温度on cooling
4. 4
   ろ過is filtered off

実験手順

A solution of 2-chloro-4-phenylamino-quinazoline (0.92 g) (prepared as described in Example 1a and N-methyl-(4-aminophenyl)-methanesulfonamide (0.80 g) in 10 ml of isopentylalcohol is stirred under nitrogen at 170° C. for 15 min in a sealed vessel. The warm reaction mixture is diluted with 10 ml ethanol and the hydrochloride salt, which is crystallizing on cooling, is filtered off to yield N-methyl-[4-(4-phenylamino-quinazolin-2-ylamino)-phenyl]-methanesulfonamide hydrochloride as light yellow crystals melting at 259-263° C.; Rf (A2) 0.11, FAB-MS: (M+H)+=420. Analytical data: C22H21N5O2S+HCl.

出典