反応 #78726

ord-b8fda62f08b94d5992ff3866f93cf372

反応方程式

O=[N+]([O-])c1cc(C(F)(F)F)c(Cl)cc1Cl
2,4-dichloro-5-nitrobenzotrifluoride
CCc1nc2cc(C(C)=O)ccc2n1-c1ccc(C[C@@H](C)OC(=O)NS(=O)(=O)c2ccc(C)cc2)cc1
(2R)-1-(4-aminophenyl)-2-propanol
CCc1nc2cc(C(C)=O)ccc2n1-c1ccc(C[C@@H](C)OC(=O)NS(=O)(=O)c2ccc(C)cc2)cc1
(1R)-2-[4-(5-ACETYL-2-ETHYL-1H-BENZIMIDAZOL-1-YL)PHENYL]-1-METHYLETHYL (4-METHYLPHENYL)SULFONYLCARBAMATE
→
CCc1nc2cc(C(F)(F)F)c(Cl)cc2n1-c1ccc(C[C@@H](C)OC(=O)NS(=O)(=O)c2ccc(C)cc2)cc1
title compound
CCc1nc2cc(C(F)(F)F)c(Cl)cc2n1-c1ccc(C[C@@H](C)OC(=O)NS(=O)(=O)c2ccc(C)cc2)cc1
(1R)-2-{4-[6-CHLORO-2-ETHYL-5-(TRIFLUOROMETHYL)-1H-BENZIMIDAZOL-1-YL]PHENYL}-1-METHYLETHYL (4-METHYLPHENYL)SULFONYLCARBAMATE

反応物

O=[N+]([O-])c1cc(C(F)(F)F)c(Cl)cc1Cl
2,4-dichloro-5-nitrobenzotrifluoride
CCc1nc2cc(C(C)=O)ccc2n1-c1ccc(C[C@@H](C)OC(=O)NS(=O)(=O)c2ccc(C)cc2)cc1
(2R)-1-(4-aminophenyl)-2-propanol
CCc1nc2cc(C(C)=O)ccc2n1-c1ccc(C[C@@H](C)OC(=O)NS(=O)(=O)c2ccc(C)cc2)cc1
(1R)-2-[4-(5-ACETYL-2-ETHYL-1H-BENZIMIDAZOL-1-YL)PHENYL]-1-METHYLETHYL (4-METHYLPHENYL)SULFONYLCARBAMATE

試薬

なし

反応条件

詳細条件
See reaction.notes.procedure_details.

実験手順

The title compound was prepared according to the procedure described in step 1 of Example 162 from 2,4-dichloro-5-nitrobenzotrifluoride and (2R)-1-(4-aminophenyl)-2-propanol (step 2 of Example 249).

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US06710054B2uspto-grants-2004_03