反応 #78643

反応方程式

ethyl 3-[3-(4-cyanophenyl)propionylamino]-4-formylbenzoate

ammonia

→

Methyl 2-[2-(4-cyanophenyl)ethyl]quinazoline-7-carboxylate

反応条件

後処理

1. 1
   workup.DISTILLATIONThen the solvent was distilled off
2. 2
   その他the residue was chromatographed on silica gel
3. 3
   洗浄eluted with methylene chloride containing 0 to 1% methanol

実験手順

0.6 g (1.8 mmol) of ethyl 3-[3-(4-cyanophenyl)propionylamino]-4-formylbenzoate and 10 mL of methanolic ammonia solution were agitated in a pressure vessel for 36 hours. Then the solvent was distilled off, the residue was chromatographed on silica gel and eluted with methylene chloride containing 0 to 1% methanol. Yield: 0.35 g (62% of theory); Rf value: 0.38 (silica gel, ethyl acetate/cyclohexane=1:1).

出典