反応 #78627

ord-690695924313454f80a15d441afaeee9

反応方程式

CCOC(=O)CCN(C(=O)c1ccc2c(c1)nc(CNc1ccc(C#N)cc1Cl)n2C)c1ccccc1
1-methyl-2-[N-(4-cyano-2-chlorophenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-phenyl-N-(2-ethoxycarbonylethyl)amide
Cl
hydrochloric acid
O=C([O-])[O-].[NH4+].[NH4+]
ammonium carbonate
→
CCOC(=O)CCN(C(=O)c1ccc2c(c1)nc(CNc1ccc(C(=N)N)cc1Cl)n2C)c1ccccc1.Cl
1-Methyl-2-[N-(4-amidino-2-chlorophenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-phenyl-N-(2-ethoxycarbonylethyl)amide hydrochloride
収率 82.0%

反応物

—
C28H29ClN6O3
CCOC(=O)CCN(C(=O)c1ccc2c(c1)nc(CNc1ccc(C#N)cc1Cl)n2C)c1ccccc1
1-methyl-2-[N-(4-cyano-2-chlorophenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-phenyl-N-(2-ethoxycarbonylethyl)amide
Cl
hydrochloric acid
O=C([O-])[O-].[NH4+].[NH4+]
ammonium carbonate

試薬

なし

溶媒

CCO
ethanol

反応条件

詳細条件
See reaction.notes.procedure_details.

実験手順

Prepared analogously to Example 25d from 1-methyl-2-[N-(4-cyano-2-chlorophenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-phenyl-N-(2-ethoxycarbonylethyl)amide, ethanolic hydrochloric acid, ethanol, and ammonium carbonate. Yield: 82% of theory, C28H29ClN6O3 (533.1); EKA mass spectrum: (M+H)+=533/5; (M+H+Na)++=278/9.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US06710055B2uspto-grants-2004_03