反応 #78606

反応方程式

4-cyanophenyloxyacetic acid

3-amino-4-methylaminophenyl-(1-methoxycarbonylmethylcyclohex-1-yl) ketone

→

crude product

3-(4-Cyanophenyloxyacetylamino)-4-methylaminophenyl-(1-methoxycarbonylmethylcyclohex-1-yl) ketone

溶媒

tetrahydrofuran

反応条件

後処理

1. 1
   その他Then the solvent was evaporated off

実験手順

620 mg (3.5 mmol) of 4-cyanophenyloxyacetic acid and 570 mg (3.5 mmol) of 1,1′-carbonylduimidazole were refluxed in 50 mL of tetrahydrofuran for 15 minutes. Then 1.0 g (3.28 mmol) of 3-amino-4-methylaminophenyl-(1-methoxycarbonylmethylcyclohex-1-yl) ketone were added and the mixture was boiled for a further 4 hours. Then the solvent was evaporated off and the crude product thus obtained was purified by column chromatography (150 g silica gel; eluant: dichloromethane with 0 to 2% ethanol). Yield: 1.4 g (93% of theory), C26H29N3O5 (463.5); Rf value: 0.44 (silica gel; dichloromethane/ethanol=19:1).

出典