反応 #78602

ord-9a5091798bd34e6bb154b3e6c1cc1747

反応方程式

CCOC(=O)CCN(C(=O)c1ccc2c(c1)nc(CN(C)c1ccc(C(=N)N)cc1)n2C)c1ccccn1.Cl
1-methyl-2-[N-(4-amidinophenyl)-N-methylaminomethyl]benzimidazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide hydrochloride
CCCCCCOC(=O)Cl
n-hexyl chloroformate
→
CCCCCCOC(=O)NC(=N)c1ccc(N(C)Cc2nc3cc(C(=O)N(CCC(=O)OCC)c4ccccn4)ccc3n2C)cc1
1-Methyl-2-[N-[4-(N-n-hexyloxycarbonylamidino)phenyl]-N-methylaminomethyl]benzimidazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide
収率 58.0%

反応物

CCOC(=O)CCN(C(=O)c1ccc2c(c1)nc(CN(C)c1ccc(C(=N)N)cc1)n2C)c1ccccn1.Cl
1-methyl-2-[N-(4-amidinophenyl)-N-methylaminomethyl]benzimidazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide hydrochloride
CCCCCCOC(=O)Cl
n-hexyl chloroformate
—
C35H43N7O5

試薬

なし

溶媒

CCO.ClCCl
dichloromethane ethanol

反応条件

詳細条件
See reaction.notes.procedure_details.

実験手順

Prepared analogously to Example 90 from 1-methyl-2-[N-(4-amidinophenyl)-N-methylaminomethyl]benzimidazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide hydrochloride and n-hexyl chloroformate. Yield: 58% of theory, C35H43N7O5 (641.2); Rf value: 0.42 (silica gel; dichloromethane/ethanol=19:1); EKA mass spectrum: (M+H)+=642; (M+H+Na)++=332.7.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US06710055B2uspto-grants-2004_03