反応 #78569

反応方程式

1-methyl-2-[N-(4-cyanophenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-(2-fluorophenyl)-N-(2-ethoxycarbonylethyl)amide

hydrochloric acid

ethanol

ammonium carbonate

→

1-Methyl-2-[N-(4-amidinophenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-(2-fluorophenyl)-N-(2-ethoxycarbonylethyl)amide hydrochloride

収率 88.0%

溶媒

dichloromethane ethanol

反応条件

実験手順

Prepared analogously to Example 25d from 1-methyl-2-[N-(4-cyanophenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-(2-fluorophenyl)-N-(2-ethoxycarbonylethyl)amide and ethanolic hydrochloric acid, ethanol, and ammonium carbonate. Yield: 88% of theory, C28H29FN6O3 (516.6); Rf value: 0.08 (silica gel; dichloromethane/ethanol=4:1); EKA mass spectrum: (M+H)+=517; (M+H+Na)++=270; (M+2H)++=259.

出典