反応 #78568

ord-0e5e524ac5644a5290391ec225b80108

反応方程式

CCOC(=O)CCN(C(=O)c1ccc2c(c1)nc(CNc1ccc(C(=N)N)cc1)n2CC)c1ccccn1.Cl
1-ethyl-2-[N-(4-amidinophenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide hydrochloride
[Na+].[OH-]
sodium hydroxide
→
CCn1c(CNc2ccc(C(=N)N)cc2)nc2cc(C(=O)N(CCC(=O)O)c3ccccn3)ccc21
1-ethyl-2-[N-(4-amidinophenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-(2-hydroxycarbonylethyl)amide
収率 49.0%

反応物

CCOC(=O)CCN(C(=O)c1ccc2c(c1)nc(CNc1ccc(C(=N)N)cc1)n2CC)c1ccccn1.Cl
1-ethyl-2-[N-(4-amidinophenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide hydrochloride
[Na+].[OH-]
sodium hydroxide
—
C26H27N7O3

試薬

なし

反応条件

詳細条件
See reaction.notes.procedure_details.

実験手順

Prepared analogously to Example 26 from 1-ethyl-2-[N-(4-amidinophenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide hydrochloride and 2N sodium hydroxide solution. Yield: 49% of theory, C26H27N7O3 (485.6); EKA mass spectrum: (M+H)+=486; (M+H+Na)++=254.6; (M+2H)++=243.6; (M+2Na)++=265.7.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US06710055B2uspto-grants-2004_03