反応 #78554

ord-1425f2c350c54162b53d9711ae9bd24b

反応方程式

CCOC(=O)CCN(C(=O)c1ccc2c(c1)nc(CN(C)c1ccc(C(=N)N)cc1)n2C)c1ccccn1.Cl
1-methyl-2-[N-(4-amidinophenyl)-N-methylaminomethyl]benzimidazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide hydrochloride
[Na+].[OH-]
sodium hydroxide
→
CN(Cc1nc2cc(C(=O)N(CCC(=O)O)c3ccccn3)ccc2n1C)c1ccc(C(=N)N)cc1
1-Methyl-2-[N-(4-amidinophenyl)-N-methylaminomethyl]benzimidazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-(2-hydroxycarbonylethyl)amide
収率 66.0%

反応物

CCOC(=O)CCN(C(=O)c1ccc2c(c1)nc(CN(C)c1ccc(C(=N)N)cc1)n2C)c1ccccn1.Cl
1-methyl-2-[N-(4-amidinophenyl)-N-methylaminomethyl]benzimidazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide hydrochloride
[Na+].[OH-]
sodium hydroxide
—
C26H27N7O3

試薬

なし

反応条件

詳細条件
See reaction.notes.procedure_details.

実験手順

Prepared analogously to Example 26 from 1-methyl-2-[N-(4-amidinophenyl)-N-methylaminomethyl]benzimidazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide hydrochloride and sodium hydroxide solution. Yield: 66% of theory, C26H27N7O3 (485.6); EKA mass spectrum: (M+H)+=486; (M+Na)+=508; (M+2Na)++=265.6.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US06710055B2uspto-grants-2004_03