反応 #78357

反応方程式

hydrochloric acid

2-amino-6-chloropurine

potassium carbonate

bromoacetic acid

→

2-Amino-6-chloro-9-carboxymethylpurine

溶媒

DMF

Water

反応条件

後処理

1. 1
   ろ過the solution was filtered through celite
2. 2
   その他to give a clear yellow solution
3. 3
   ろ過The precipitate was filtered
4. 4
   その他dried, in vacuo

実験手順

To a suspension of 2-amino-6-chloropurine (5.02 g, 29.6 mmol) and potassium carbonate (12.91 g, 93.5 mmol) in DMF (50 mL) was added bromoacetic acid (4.7 g, 22.8 mmol). The mixture was stirred vigorously for 20 h under nitrogen. Water (150 mL) was added and the solution was filtered through celite to give a clear yellow solution. The solution was acidified to a pH of 3 with 4 N hydrochloric acid. The precipitate was filtered and dried, in vacuo, over sicapent. Yield: 3.02 g (44.8%). 1H-NMR(DMSO-d6) δ: 4.88 ppm (s, 2H); 6.95 (s, 2H); 8.10 (s, 1H).

出典