反応 #78341

反応方程式

hydrogen chloride

4-benzyl-4-cyanopiperidine

compound

1-Benzoyl-3-(3,4-dichlorophenyl)-3-[3-[4-(pyrrolidin-1-ylcarbonyl)piperid-1-yl]propyl]piperidine Hydrochloride

K2CO3

→

expected product

収率 105.6%

1-Benzoyl-3-[3-(4-benzyl-4-cyanopiperid-1-yl)propyl]-3-(3,4-dichloro-phenyl)piperidine Hydrochloride Monohydrate

収率 105.6%

溶媒

DMF

反応条件

後処理

1. 1
   その他This compound is prepared by the procedure
2. 2
   その他The product obtained
3. 3
   その他is chromatographed on silica H
4. 4
   その他The product obtained
5. 5
   その他the solvent is evaporated off under vacuum

実験手順

This compound is prepared by the procedure described in EXAMPLE 4, starting from 2.5 g of 4-benzyl-4-cyanopiperidine, 5 g of the compound obtained in step B of EXAMPLE 1, 3.7 g of K2CO3 and 50 ml of DMF. The product obtained is chromatographed on silica H using DCM and then a DCM/MeOH mixture (97/3; v/v) as the eluent. The product obtained is taken up with ethereal hydrogen chloride and the solvent is evaporated off under vacuum to give 2.8 g of the expected product after crystallization from iso ether.

出典