反応 #78102

反応方程式

4-fluorophenylacetic acid

nitric acid

→

1i

収率 70.5%

4-Fluoro-3-nitrophenylacetic acid

収率 70.5%

溶媒

sulfuric acid

反応条件

後処理

1. 1
   その他at 0-5° C
2. 2
   workup.ADDITIONAt the end of the addition the mixture
3. 3
   ろ過The precipitate was filtered off
4. 4
   洗浄washed thoroughly with water
5. 5
   その他dried with suction

実験手順

A suspension of 4-fluorophenylacetic acid (10.0 g, 64.9 mmol) in concentrated sulfuric acid (100 ml) was cooled to 0° C. Concentrated nitric acid (4.5 ml, 65 mmol) was added drop-wise, keeping the temperature at 0-5° C. At the end of the addition the mixture was poured into ice-water (400 ml). The precipitate was filtered off, washed thoroughly with water and dried with suction to yield 1i (9.11 g, 70%).

出典