反応 #7810

反応方程式

2-[3-(methoxymethoxy)-4-methylphenyl]-1,3-benzoxazole

NBS

benzoyl peroxide

→

2-[4-(bromomethyl)-3-(methoxymethoxy)phenyl]-1,3-benzoxazole

溶媒

CCl4

反応条件

後処理

1. 1
   その他CCl4 was removed in vacuo and residue
2. 2
   その他was purified by flash column (silica gel, hexanes:EtOAc 5:1)

実験手順

A solution of 2-[3-(methoxymethoxy)-4-methylphenyl]-1,3-benzoxazole (200 mg, 0.74 mmol, 84%), NBS (179 mg, 0.81 mmol), and benzoyl peroxide (50 mg) in CCl4 (10 mL), was refluxed for 12 h. After cooling to rt, CCl4 was removed in vacuo and residue was purified by flash column (silica gel, hexanes:EtOAc 5:1) to afford 2-[4-(bromomethyl)-3-(methoxymethoxy)phenyl]-1,3-benzoxazole. MS (ESI) 349 (M+H)+.

出典