反応 #78078

反応方程式

water

5-bromo-2,4-dichloropyrimidine

4-methoxyphenol

potassium carbonate

→

product

収率 96.0%

5-Bromo-2-chloro-4-(4-methoxyphenoxy)pyrimidine

収率 96.0%

溶媒

DMF

反応条件

後処理

1. 1
   その他the solid which separated out
2. 2
   ろ過was collected by filtration
3. 3
   洗浄washed with water (50 ml)
4. 4
   その他dried under high vacuum

実験手順

A mixture of 5-bromo-2,4-dichloropyrimidine (5.0 g, 22.0 mmol), 4-methoxyphenol (2.72 g, 22.0 mmol) and potassium carbonate (6.07 g, 44.0 mmol) in DMF (20 ml) was stirred for 24 hours. The mixture was added to water (100 ml) and the solid which separated out was collected by filtration, washed with water (50 ml) and dried under high vacuum to give the product (6.6 g, 96%). NMR: 3.8 (s, 3H), 7.0 (d, 2H), 7.2 (d, 2H), 8.8 (s, 11H).

出典