反応 #77927

反応方程式

hydrochloric acid

guanidinium chloride

sodium methoxide

methyl 4,5-bismethanesulfonyl-2-methylbenzoate

→

N-(4,5-bis-methanesulfonyl-2-methylbenzoyl)guanidinium chloride

溶媒

THF

methanol

反応条件

後処理

1. 1
   workup.ADDITIONwere introduced into the mixture
2. 2
   workup.STIRRINGAfter the mixture had been stirred at 10° C. for 1 h

実験手順

87.4 ml of THF, were added with stirring to 50.4 g of a 30% sodium methoxide solution in methanol. 28.95 g of guanidinium chloride were subsequently introduced. The suspension was stirred at 16-24° C. for 2 h and cooled to 10° C., before 30.8 g of methyl 4,5-bismethanesulfonyl-2-methylbenzoate were introduced into the mixture. After the mixture had been stirred at 10° C. for 1 h, a corresponding amount of a hydrochloric acid solution was added to the mixture. Conventional work-up gave N-(4,5-bis-methanesulfonyl-2-methylbenzoyl)guanidinium chloride.

出典