反応 #7789

反応方程式

2-[4-methyl-3-(trifluoromethyl)phenyl]-1,3-benzoxazole

n-bromosuccinimide

benzoyl peroxide

→

2-[4-(bromomethyl)-3-(trifluoromethyl)phenyl]-1,3-benzoxazole

溶媒

carbon tetrachloride

反応条件

後処理

1. 1
   温度was refluxed for 3 h
2. 2
   ろ過The white precipitate was filtered
3. 3
   濃縮the filtrate was concentrated to dryness
4. 4
   その他The crude was purified by flash chromatography on silica gel eluting with EtOAc:hexanes (1:1)

実験手順

A mixture of 2-[4-methyl-3-(trifluoromethyl)phenyl]-1,3-benzoxazole (600 mg, 2.2 mmol), n-bromosuccinimide (579 mg, 3.25 mmol), benzoyl peroxide (26 mg, 0.11 mmol) in carbon tetrachloride (15 mL) was refluxed for 3 h and then cooled to rt. The white precipitate was filtered and the filtrate was concentrated to dryness. The crude was purified by flash chromatography on silica gel eluting with EtOAc:hexanes (1:1) to afford 2-[4-(bromomethyl)-3-(trifluoromethyl)phenyl]-1,3-benzoxazole.

出典