反応 #77824

反応方程式

4-[3-[1(S)-(4-Chlorophenyl)ethyl]1-(4-cyclohexylphenyl)ureidomethyl]benzoic acid methyl ester

sodium hydroxide

hydrochloric acid

→

4-[3-[1(S)-(4-Chlorophenyl)ethyl]1-(4-cyclohexylphenyl)ureidomethyl]benzoic acid

溶媒

ethanol

反応条件

後処理

1. 1
   その他placed upon an ice bath
2. 2
   その他crystallization
3. 3
   その他The crystals were collected
4. 4
   洗浄washed extensively with water
5. 5
   その他dried in vacuo over night

実験手順

4-[3-[1(S)-(4-Chlorophenyl)ethyl]1-(4-cyclohexylphenyl)ureidomethyl]benzoic acid methyl ester (35.0 g, 69.3 mmol) was dissolved in ethanol (400 ml). 4 N aqueous sodium hydroxide (100 ml) was added and the clear solution was stirred at room temperature for 3 hours. The solution was neutralised with 4 N hydrochloric acid (100 ml), and placed upon an ice bath to initiate crystallization. The crystals were collected, washed extensively with water, and dried in vacuo over night. Yield: 34.25 g (100%).

出典