反応 #77808

反応方程式

5-amino-2-methoxy-N-(4-trifluoromethylbenzyl)benzamide

hydrobromic acid

sodium nitrite

acrylamide

→

5-(2-bromo-2-carbamoylethyl)-2-methoxy-N-(4-trifluoromethylbenzyl)benzamide

溶媒

acetone

methanol

water

反応条件

後処理

1. 1
   温度under cooling with ice
2. 2
   workup.STIRRINGwas stirred further for 2 hours at 30° C
3. 3
   workup.DISTILLATIONSolvent was distilled off under reduced pressure, and 25% aqueous ammonia
4. 4
   workup.ADDITIONwas added to the residue, which
5. 5
   抽出was extracted with ethyl acetate
6. 6
   洗浄The organic layer was washed with water and saturated brine in sequence
7. 7
   乾燥dried over anhydrous sodium sulfate
8. 8
   workup.DISTILLATIONSolvent was distilled off under reduced pressure
9. 9
   その他the residue obtained
10. 10
    その他was crystallized from hexane
11. 11
    ろ過ethyl acetate=1:1, and then the crystals were collected by filtration

実験手順

To a solution of 2.26 g of 5-amino-2-methoxy-N-(4-trifluoromethylbenzyl)benzamide in 27 ml of acetone and 11 ml of methanol were added 5.6 ml of 47% solution of hydrobromic acid, 540 mg of sodium nitrite and 2 ml of water under cooling with ice, and the mixture was stirred for 10 minutes. To the reaction mixture were added 3.00 g of acrylamide, and, after heated to 30° C., 135 mg of cupric oxide were added little by little, and the mixture was stirred further for 2 hours at 30° C. Solvent was distilled off under reduced pressure, and 25% aqueous ammonia was added to the residue, which was extracted with ethyl acetate. The organic layer was washed with water and saturated brine in sequence and dried over anhydrous sodium sulfate. Solvent was distilled off under reduced pressure, the residue obtained was crystallized from hexane:ethyl acetate=1:1, and then the crystals were collected by filtration to obtain 1.55 g of 5-(2-bromo-2-carbamoylethyl)-2-methoxy-N-(4-trifluoromethylbenzyl)benzamide as colorless crystals.

出典