反応 #77738

反応方程式

ethyl 7-amino-2-chromancarboxylate

lithium borohydride

→

title compound

収率 90.0%

7-Amino-2-(hydroxymethyl)chroman

収率 90.0%

溶媒

THF

反応条件

後処理

1. 1
   その他quenched with methanol
2. 2
   workup.STIRRINGstirred at ambient temperatures for 1 h
3. 3
   workup.ADDITIONpoured into water
4. 4
   抽出extracted with ethyl acetate
5. 5
   乾燥dried over MgSO4
6. 6
   濃縮concentrated in vacuo

実験手順

A solution of ethyl 7-amino-2-chromancarboxylate (1.26 g, 5.7 mmol) in anhydrous THF is treated dropwise with lithium borohydride (2.0 M in THF, 13.7 mmol), stirred under nitrogen at ambient temperatures for 4 h, quenched with methanol, stirred at ambient temperatures for 1 h, poured into water, extracted with ethyl acetate. The extracts are combined, dried over MgSO4 and concentrated in vacuo to afford the title compound as a nearly colorless oil, 0.9 g (90% yield), identified by NMR and mass spectral analyses.

出典