反応 #77570

反応方程式

1,4-bis(5-bromo-2-pyridyl)hexahydro-1,4-diazepine

4-trifluoromethylphenylboronic acid

→

title compound

収率 40.6%

1,4-Bis[5-(4-trifluoromethylphenyl)-2-pyridyl]hexahydro-1,4-diazepine

収率 40.6%

反応条件

後処理

1. 1
   その他The crude crystals were recrystallized from chloroform-hexane

実験手順

Following the procedure of Example 1, crude crystals were obtained from the 1,4-bis(5-bromo-2-pyridyl)hexahydro-1,4-diazepine (206.0 mg, 0.500 mmol) synthesized in Reference Example 1 and 4-trifluoromethylphenylboronic acid (227.0 mg, 1.20 mmol). The crude crystals were recrystallized from chloroform-hexane to yield the title compound as colorless needles (melting point: 236.0-238.0° C.) (110.0 mg, yield: 40%).

出典