反応 #77474

反応方程式

acetone

2-chloro-5-fluorobenzaldehyde

Sodium hydroxide

acetone

→

4-(2-chloro-5-fluorophenyl)-3-buten-2-one

溶媒

water

反応条件

後処理

1. 1
   workup.DISTILLATIONAcetone was distilled off under reduced pressure
2. 2
   抽出the residue was extracted with ethyl acetate
3. 3
   洗浄The organic layer was washed successively with water and saturated brine
4. 4
   濃縮concentrated under reduced 5 pressure

実験手順

Sodium hydroxide (0.78 g) was dissolved in water (55 ml) and treated dropwise with acetone (55 ml) followed by a solution of 2-chloro-5-fluorobenzaldehyde (2.8 g) in acetone (10 ml). The reaction mixture was stirred at room temperature for 2 hours. Acetone was distilled off under reduced pressure, and the residue was extracted with ethyl acetate. The organic layer was washed successively with water and saturated brine, and concentrated under reduced 5 pressure to obtain 4-(2-chloro-5-fluorophenyl)-3-buten-2-one (0.24 g).

出典