反応 #77389

反応方程式

5-chlorosulfonyl-2-oxindole

4-fluorobenzylamine

pyridine

→

2-oxo-2,3-dihydro-1H-indole-5-sulfonic acid-4-fluoro-benzylamide

収率 84.0%

溶媒

dichloromethane

反応条件

後処理

1. 1
   ろ過The precipitate was filtered
2. 2
   洗浄washed with dichloromethane
3. 3
   その他dried

実験手順

A suspension of 5-chlorosulfonyl-2-oxindole (5.0 g), 4-fluorobenzylamine (3.0 mL) and pyridine (3.5 mL) in dichloromethane (30 mL) was stirred at room temperature for 4 hours. The precipitate was filtered, washed with dichloromethane and dried to give 5.8 g (84%) of 2-oxo-2,3-dihydro-1H-indole-5-sulfonic acid-4-fluoro-benzylamide.

出典