反応 #77367

反応方程式

2-oxo-2,3-dihydro-1H-indole-5-sulfonic acid amide

5-(2-morpholin-4-yl-ethoxy)-1H-indole-2-carbaldehyde

piperidine

→

title compound

収率 73.7%

3-[5-(2-Morpholin-4-yl-ethoxy)-1H-indol-2-ylmethylene]-2-oxo-2,3-dihydro-1H-indole-5-sulfonic acid amide

収率 73.7%

溶媒

ethanol

反応条件

後処理

1. 1
   温度The reaction was cooled at 0° C. for overnight
2. 2
   ろ過The precipitate was collected by vacuum filtration
3. 3
   洗浄washed with cold ethanol
4. 4
   その他dried

実験手順

A mixture of 2-oxo-2,3-dihydro-1H-indole-5-sulfonic acid amide (27 mg, 0.12 mmol), 5-(2-morpholin-4-yl-ethoxy)-1H-indole-2-carbaldehyde (30 mg, 0.11 mmol) and piperidine (0.1 mL) in ethanol (1 mL) was heated at 90° C. for 2 hours. The reaction was cooled at 0° C. for overnight. The precipitate was collected by vacuum filtration, washed with cold ethanol and dried to give 38 mg (62%) of the title compound as an orange solid.

出典