反応 #77332

反応方程式

[5-(3-diethylamino-propyl)-1H-indol-2-yl]-methanol

→

5-(3-diethylamino-propyl)-1H-indole-2-carbaldehyde

収率 86.1%

溶媒

dichloromethane

反応条件

後処理

1. 1
   ろ過The precipitate was filtered through celite
2. 2
   洗浄washing with hot dichloromethane
3. 3
   濃縮The filtrate was concentrated

実験手順

Manganese oxide (3.75 g, 43.1 mmol) was added portionwise to [5-(3-diethylamino-propyl)-1H-indol-2-yl]-methanol (660 mg, 2.53 mmol) dissolved in dichloromethane (68 mL) under nitrogen at room temperature. The precipitate was filtered through celite, washing with hot dichloromethane. The filtrate was concentrated to give 563 mg (83%) of 5-(3-diethylamino-propyl)-1H-indole-2-carbaldehyde as a waxy brown solid.

出典