反応 #7721

反応方程式

7-Fluoro-3H-quinazolin-4-one

2-amino-4-fluorobenzoic acid

formamidine acetate

2-methoxyethanol

→

title compound

収率 81.0%

2-[7-(3-Fluoro-benzyloxy)-4-oxo-4H-quinazolin-3-yl]-acetamide

収率 81.0%

溶媒

ammonia

反応条件

後処理

1. 1
   温度After cooling
2. 2
   その他evaporated
3. 3
   その他an off-white solid formed
4. 4
   ろ過the solid filtered off
5. 5
   洗浄washed with water
6. 6
   洗浄The solid was then washed with hexane
7. 7
   その他dried under high vacuum

実験手順

7-Fluoro-3H-quinazolin-4-one: A mixture of 2-amino-4-fluorobenzoic acid (14.6 g, 94 mmol) and formamidine acetate (19.6 g, 18.8 mmol) in 2-methoxyethanol (110 mL) was heated at 130° C. for 18 h. After cooling, the mixture was half evaporated and an off-white solid formed. The mixture was diluted with ammonia (25%, 10 mL in 90 mL water) and the solid filtered off and washed with water. The solid was then washed with hexane and dried under high vacuum to afford the title compound (12.5 g, 81%) as an off-white solid. MS: m/e=165.2 (M+H+).

出典