反応 #7696

反応方程式

NaHMDS

(R)-N-benzyl-3-methyl-N′-cyanomethylpiperazine

2-cyano-5-methoxy-benzothiazole

THF

→

(R)-N-(benzoyl)-3-methyl-N′-[2-(5-methoxy-benzothiazol-2-yl)-2-imino-1-cyano-ethyl]-piperazine

反応条件

後処理

1. 1
   その他Then 4 ml of the reaction mixture was separated
2. 2
   その他quenched with MeOH
3. 3
   その他After solvents were removed under vaccum
4. 4
   その他the residue was purified

実験手順

NaHMDS (0.77 ml, 1M in THF) was added into a solution of (R)-N-benzyl-3-methyl-N′-cyanomethylpiperazine (100 mg) and 2-cyano-5-methoxy-benzothiazole (58 mg) in THF (10 ml). The reaction was stirred for 10 hours. Then 4 ml of the reaction mixture was separated and quenched with MeOH. After solvents were removed under vaccum, the residue was purified using Shimadzu automated preparative HPLC System to give (R)-N-(benzoyl)-3-methyl-N′-[2-(5-methoxy-benzothiazol-2-yl)-2-imino-1-cyano-ethyl]-piperazine (1.3 mg).

出典