反応 #7695

反応方程式

NaHMDS

(R)-N-benzoyl-3-methyl-N′-(2-cyano-acetyl)piperazine

2-chlorobenzothiazole

→

(R)-N-(benzoyl)-3-methyl-N′-[(benzothiazol-2-yl)-2-cyanoacetyl]-piperazine

収率 6.5%

溶媒

THF

反応条件

後処理

1. 1
   その他4 ml of solution was separated
2. 2
   その他quenched with MeOH
3. 3
   その他After solvents were removed under vaccum
4. 4
   その他the residue was purified

実験手順

NaHMDS (1.48 ml, 1M in THF) was added into a solution of (R)-N-benzoyl-3-methyl-N′-(2-cyano-acetyl)piperazine (190 mg) and 2-chlorobenzothiazole (100 mg) in THF (10 ml). After the reaction was stirred for 10 hours, 4 ml of solution was separated and quenched with MeOH. After solvents were removed under vaccum, the residue was purified using Shimadzu automated preparative HPLC System to give (R)-N-(benzoyl)-3-methyl-N′-[(benzothiazol-2-yl)-2-cyanoacetyl]-piperazine (15.4 mg).

出典