反応 #7694

反応方程式

chloroacetonitrile

benzylpiperazine

→

N-benzyl-N′-cyanomethylpiperazine

溶媒

THF

Et3N

反応条件

後処理

1. 1
   その他before quenched with saturated aqueous NaHCO3 (100 ml)
2. 2
   抽出The aqueous phase was extracted with EtOAc (3×100 ml)
3. 3
   乾燥The combined organic layer was dried over MgSO4
4. 4
   濃縮concentrated to a residue, which
5. 5
   その他was used in the further reactions without any purification

実験手順

An excess of chloroacetonitrile (7 ml) was added in to a solution of benzylpiperazine (2 g, 10.5 mmol) in THF (100 ml) and Et3N (10 ml). The reaction was stirred for 10 hours before quenched with saturated aqueous NaHCO3 (100 ml). The aqueous phase was extracted with EtOAc (3×100 ml). The combined organic layer was dried over MgSO4 and concentrated to a residue, which was used in the further reactions without any purification.

出典