反応 #76848

反応方程式

1-[(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydro-naphthalen-2-yl]-phenyl-acetic acid methyl ester

NaOH

→

titled product

1-[(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydro-naphthalen-2-yl]-phenyl-acetic acid

溶媒

dioxane MeOH

反応条件

後処理

1. 1
   濃縮The mixture was then concentrated in vacuo
2. 2
   抽出extracted three times with with CH2Cl2
3. 3
   乾燥the combined organic phases were dried over anhydrous MgSO4
4. 4
   ろ過filtered
5. 5
   濃縮concentrated

実験手順

To a solution of 1-[(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydro-naphthalen-2-yl]-phenyl-acetic acid methyl ester (5.85 g, 0.011 mmol) in a mixture dioxane/MeOH (4/3) (160 ml) was added dropwise 2M NaOH(aq) (81 ml). The resulting mixture was stirred at RT for 20 h under nitrogen. The mixture was then concentrated in vacuo, combined with water and AcOEt. The aqueous phase was acidified until pH 1 with 2N HCl, extracted three times with with CH2Cl2, the combined organic phases were dried over anhydrous MgSO4, filtered and concentrated to give the titled product (5.55 g, 97%) as yellow-green crystals.

出典