反応 #76808

反応方程式

dicumarol

p-toluenesulfonyl chloride

→

3,3′-methylenebis[4-tosylcoumarin]

溶媒

dichloromethane

triethylamine

反応条件

後処理

1. 1
   その他the reaction mixture was evaporated
2. 2
   その他the residue was purified by flash chromatography (silica gel)

実験手順

To a solution of dicumarol (10 mmol) and p-toluenesulfonyl chloride (1.0 eq.) in dichloromethane (20 ml), triethylamine was added at room temperature under air atmosphere. After the reaction was complete, as monitored by TLC, the reaction mixture was evaporated and the residue was purified by flash chromatography (silica gel) to afford the product, 3,3′-methylenebis[4-tosylcoumarin].

出典