反応 #76775

反応方程式

tin(II)chloride

ethyl 5-amino-2-chlorocinnamate

sodium nitrite

→

ethyl 2-chloro-5-hydrazinocinnamate

収率 34.5%

溶媒

hydrochloric acid

反応条件

後処理

1. 1
   workup.ADDITIONwas added dropwise at 0° C.
2. 2
   ろ過the precipitated crystals were collected by filtration
3. 3
   workup.ADDITIONThese crystals were added to ice-water
4. 4
   抽出extracted with chloroform
5. 5
   乾燥The chloroform layer was dried
6. 6
   濃縮concentrated

実験手順

First, 60 g of tin(II)chloride was dissolved in 60 ml of concentrated hydrochloric acid, and the mixture was cooled to −30° C., to which a diazonium solution prepared from 19 g of ethyl 5-amino-2-chlorocinnamate and 6.3 g of sodium nitrite was added dropwise at 0° C. or lower. The reaction mixture was stirred at room temperature for 1 hour, and the precipitated crystals were collected by filtration. These crystals were added to ice-water, neutralized with 2N aqueous sodium hydroxide, and extracted with chloroform. The chloroform layer was dried and concentrated, which afforded 7.0 g of ethyl 2-chloro-5-hydrazinocinnamate.

出典