反応 #76771

反応方程式

methyl 2-bromo-4-fluoro-5-nitrophenoxyformate

sodium hydroxide

→

2-bromo-4-fluoro-5-nitrophenol

収率 100.0%

溶媒

water

反応条件

後処理

1. 1
   workup.ADDITIONwas added
2. 2
   その他After completion of the reaction
3. 3
   洗浄washed with chloroform
4. 4
   抽出extracted with ethyl acetate
5. 5
   乾燥The ethyl acetate layer was dried
6. 6
   濃縮concentrated

実験手順

Then, 125 g (0.43 mol) of methyl 2-bromo-4-fluoro-5-nitrophenoxyformate was suspended in 200 ml of water, to which 19 g (0.47 mol) of sodium hydroxide was added, and the mixture was stirred at 50° to 60° C. for 4 hours. After completion of the reaction, the reaction mixture was cooled to room temperature and washed with chloroform. The aqueous layer was acidified with aqueous hydrochloric acid and extracted with ethyl acetate. The ethyl acetate layer was dried and concentrated, which afforded 104 g (0.43 mol) of 2-bromo-4-fluoro-5-nitrophenol.

出典