反応 #76770

反応方程式

methyl 2-bromo-4-fluorophenoxyformate

nitric acid

→

methyl 2-bromo-4-fluoro-5-nitrophenoxyformate

収率 97.7%

溶媒

sulfuric acid

sulfuric acid

反応条件

後処理

1. 1
   workup.ADDITIONwas added dropwise at 5° C.
2. 2
   workup.ADDITIONThe reaction mixture was poured onto ice
3. 3
   ろ過the precipitated crystals were collected by filtration
4. 4
   洗浄washed with water
5. 5
   その他dried

実験手順

Then, 110 g (0.44 mol) of methyl 2-bromo-4-fluorophenoxyformate was dissolved in 250 ml of sulfuric acid, to which a mixed acid of 30 g of fuming nitric acid and 30 ml of sulfuric acid was added dropwise at 5° C. or lower, and the mixture was stirred for 2 hours. The reaction mixture was poured onto ice, and the precipitated crystals were collected by filtration, washed with water, and dried, which afforded 126 g (0.43 mol) of methyl 2-bromo-4-fluoro-5-nitrophenoxyformate.

出典