反応 #76769

反応方程式

sodium hydroxide

2-bromo-4-fluorophenol

methyl chloroformate

→

methyl 2-bromo-4-fluorophenoxyformate

収率 91.8%

溶媒

water

water

反応条件

後処理

1. 1
   ろ過The precipitated crystals were collected by filtration
2. 2
   洗浄washed with water
3. 3
   その他dried in a vacuum oven, which

実験手順

First, 93 g (0.49 mol) of 2-bromo-4-fluorophenol was suspended in 200 ml of water, into which 55 g (0.59 mol) of methyl chloroformate and a solution of 21.5 g (0.51 mol) of sodium hydroxide in 60 ml of water were poured together at 10° C. or lower, and the mixture was stirred at the same temperature for 2 hours. The precipitated crystals were collected by filtration, washed with water, and dried in a vacuum oven, which afforded 111.6 g (0.45 mol) of methyl 2-bromo-4-fluorophenoxyformate.

出典