反応 #76768

反応方程式

sodium acetate

1,1-dibromo-3,3,3-trifluoroacetone

4-bromo-2-fluoro-5-isopropoxyphenylhydrazine hydrochloride

→

3,3,3-trifluoro-2-oxopropanal 1-(4-bromo-2-fluoro-5-isopropoxyphenylhydrazone)

収率 67.4%

溶媒

water

反応条件

後処理

1. 1
   温度cooled to 0° C
2. 2
   workup.STIRRINGlower, and the mixture was stirred at 10° C. or lower for 3 hours
3. 3
   ろ過The precipitated crystals were collected by filtration
4. 4
   その他dried

実験手順

First, 50 g (0.61 mol) of sodium acetate and 41 g (0.14 mol) of 1,1-dibromo-3,3,3-trifluoroacetone were mixed with 500 ml of water, and the mixture was stirred at 80° C. for 30 minutes and then cooled to 0° C. Then, 45 g (0.14 mol) of 4-bromo-2-fluoro-5-isopropoxyphenylhydrazine hydrochloride was added at 10° C. or lower, and the mixture was stirred at 10° C. or lower for 3 hours. The precipitated crystals were collected by filtration and dried, which afforded 35 g (94.3 mmol) of 3,3,3-trifluoro-2-oxopropanal 1-(4-bromo-2-fluoro-5-isopropoxyphenylhydrazone).

出典