反応 #76747

反応方程式

methyl 5-(4-fluorophenyl)nicotinate

methyl 5-bromopyridine-3-carboxylate

4-fluorobenzeneboronic acid

→

5-(4-fluorophenyl)nicotinic acid

反応条件

実験手順

15.3 g of methyl 5-(4-fluorophenyl)nicotinate (obtainable by Suzuki coupling of methyl 5-bromopyridine-3-carboxylate with 4-fluorobenzeneboronic acid analogously to Example 1 or 2) are saponified by conventional methods to give 5-(4-fluorophenyl)nicotinic acid.

出典