反応 #76563

反応方程式

carbon dioxide

7-Fluoro-4-hydroxy-3-quinolinecarboxylic acid

carbon dioxide

7-fluoro-4-hydroxy-3-quinolinecarboxylic acid

→

7-fluoro-4-quinolinol

収率 180.8%

反応条件

後処理

1. 1
   その他The resulting solid was isolated by filtration

実験手順

7-Fluoro-4-hydroxy-3-quinolinecarboxylic acid (25 g) was placed in a round bottom flask and heated to 330-350° C. at which time carbon dioxide liberation commenced and the material began to liquefy. After about 2 minutes an additional 25 g of 7-fluoro-4-hydroxy-3-quinolinecarboxylic acid was added. The heating was continued for an additional 4 to 6 minutes at which time there was no further evolution of carbon dioxide. The solution was allowed to cool to ambient temperature. The resulting solid was isolated by filtration to provide 35.6 g of 7-fluoro-4-quinolinol as a pink solid.

出典