反応 #76562

反応方程式

ethyl 7-fluoro-4-hydroxy-3-quinolinecarboxylate

→

7-fluoro-4-hydroxy-3-quinolinecarboxylic acid

収率 92.2%

溶媒

sodium hydroxide

反応条件

後処理

1. 1
   温度was heated
2. 2
   温度at reflux for 3 hours during which time a solution
3. 3
   その他was obtained
4. 4
   ろ過it was filtered
5. 5
   ろ過through filter paper under vacuum
6. 6
   その他The resulting precipitate was collected
7. 7
   洗浄washed with water
8. 8
   その他dried

実験手順

A suspension of ethyl 7-fluoro-4-hydroxy-3-quinolinecarboxylate (65 g, 0.28 mol) in 10% sodium hydroxide (250 mL) was heated at reflux for 3 hours during which time a solution was obtained. The reaction mixture was allowed to cool to ambient temperature and then it was filtered through filter paper under vacuum. The filtrate was acidified with concentrated hydrochloric acid. The resulting precipitate was collected, washed with water and then dried to provide 53.5 g of 7-fluoro-4-hydroxy-3-quinolinecarboxylic acid as a white solid.

出典