反応 #76510

反応方程式

5-amino-6-nitroquinoline

triethylamine

ethyloxalyl chloride

dimethylformamide

→

title compound

収率 80.0%

[(6-Nitro-5-quinolinyl)amino]oxo-acetic acid ethyl ester

収率 80.0%

反応条件

後処理

1. 1
   その他After removing the triethylamine hydrochloride
2. 2
   ろ過by filtration
3. 3
   濃縮the filtrate was concentrated
4. 4
   workup.ADDITIONdiethyl ether added

実験手順

A solution of 5-amino-6-nitroquinoline (3 g, 16 mmol) in 50 mL dimethylformamide was treated with triethylamine (3.2 g, 32 mmol) and ethyloxalyl chloride (3.2 g, 24 mmol) and heated at 50° C. for 1 hour. After removing the triethylamine hydrochloride by filtration, the filtrate was concentrated and diethyl ether added. The title compound (3.7 g, 80% yield) was collected by filtration.

出典