反応 #76506

反応方程式

product

6-Amino-1,4,7,8,9,10-hexahydro-9-methyl-pyrido-[3,4-f]quinoxaline-2,3-dione

acetic acid

→

title compound

N-(1,2,3,4,7,8,9,10-Octahydro-9-methyl-2,3-dioxopyrido[3,4-f]quinoxalin-6-yl) acetamide

溶媒

acetic anhydride

反応条件

後処理

1. 1
   その他After removing the solvent
2. 2
   洗浄the residue was washed with ether
3. 3
   workup.DISSOLUTIONdissolved in water
4. 4
   温度The flask was cooled in the freezer for 2 hours
5. 5
   ろ過the precipitate collected by filtration
6. 6
   洗浄washed consecutively with water and ether
7. 7
   乾燥dried over P2O5 in vacuo

実験手順

A mixture of the product from Example 79 (0.27 g, 1.1 mmol) in 25 mL acetic acid and 10 mL acetic anhydride was stirred at room temperature for 18 hours. After removing the solvent, the residue was washed with ether, dissolved in water and then basified with saturated sodium bicarbonate. The flask was cooled in the freezer for 2 hours and the precipitate collected by filtration, washed consecutively with water and ether, and dried over P2O5 in vacuo to give the title compound (0.2 g).

出典