反応 #76503

反応方程式

9-ethyl-1,4,7,8,9,10-hexahydro-pyrido[3,4-f]quinoxaline-2,3-dione

potassium nitrate

Ammonium hydroxide

→

9-Ethyl-1,4,7,8,9,10-hexahydro-6-nitro-pyrido[3,4-f]quinoxaline-2,3-dione

収率 94.0%

溶媒

sulfuric acid

sulfuric acid

反応条件

後処理

1. 1
   workup.ADDITIONthe reaction mixture was poured onto ice
2. 2
   温度cooled in an isopropyl alcohol/dry ice bath
3. 3
   ろ過the yellow solid was collected by filtration (0.59 g, 94% yield)

実験手順

A solution of 9-ethyl-1,4,7,8,9,10-hexahydro-pyrido[3,4-f]quinoxaline-2,3-dione (0.61 g, 2.16 mmol) in 20 mL of concentrated sulfuric acid was treated with a solution of potassium nitrate (0.25 g, 2.47 mmol) in 2 mL concentrated sulfuric acid. After stirring for 3 hours at room temperature, the reaction mixture was poured onto ice and cooled in an isopropyl alcohol/dry ice bath. Ammonium hydroxide was added to adjust the pH to 8.9, and the yellow solid was collected by filtration (0.59 g, 94% yield).

出典