反応 #76479

反応方程式

5-nitroisoquinoline

iodoethane

EtOH

→

title compound

N-(2-ethyl-1,2,3,4-tetrahydro-5-isoquinolinyl)acetamide

反応条件

後処理

1. 1
   温度the resulting solution heated
2. 2
   温度at reflux for 24 hours
3. 3
   温度The reaction mixture was cooled
4. 4
   その他the material which formed
5. 5
   その他was collected
6. 6
   その他dried
7. 7
   その他The material obtained

実験手順

A solution of 5-nitroisoquinoline (25 g, 0.144 mol) in 250 mL of EtOH was treated with iodoethane (26.9 g, 0.172 mol) and the resulting solution heated at reflux for 24 hours. The reaction mixture was cooled and the material which formed was collected and dried. The material obtained was converted to the title compound by the procedures described in Example 1. A white solid was obtained (4.42 g, 17%).

出典