反応 #76426

反応方程式

Methyl(4-hydroxy-3-nitrophenyl)acetate

methyl(4-hydroxy-3-nitrophenyl)acetate

→

methyl(3-amino-4-hydroxyphenyl)acetate

収率 98.4%

溶媒

methanol

反応条件

後処理

1. 1
   その他had been consumed
2. 2
   ろ過The reaction mixture was filtered
3. 3
   その他to remove the catalyst
4. 4
   洗浄the filtercake was washed with methanol
5. 5
   濃縮The combined filtrate and washings were concentrated in vacuo

実験手順

Methyl(4-hydroxy-3-nitrophenyl)acetate [from step 3] (48.9 g, 0.23 mole) and 5% palladium on carbon were suspended in methanol and the resulting mixture was hydrogenated until all the starting material had been consumed. The reaction mixture was filtered to remove the catalyst and the filtercake was washed with methanol. The combined filtrate and washings were concentrated in vacuo, affording methyl(3-amino-4-hydroxyphenyl)acetate as a solid (41.0 g).

出典