反応 #76373

反応方程式

magnesium

trans-1-pentyl-4-(trans-4-chloromethylcyclohexyl)cyclohexane

tetramethoxysilane

→

trans-1-pentyl-4-(trans-4-trimethoxysilylmethyl-cyclohexyl)cyclohexane

収率 65.0%

溶媒

THF

THF

反応条件

後処理

1. 1
   workup.WAITafter left standing
2. 2
   温度for cooling
3. 3
   ろ過the reaction mixture was filtered
4. 4
   workup.DISTILLATIONThe solvent was distilled off

実験手順

A Grignard reagent was prepared from 100 ml of THF, magnesium (120 mmole) and trans-1-pentyl-4-(trans-4-chloromethylcyclohexyl)cyclohexane (100 mmole) under nitrogen atmosphere. A THF 100 ml solution of tetramethoxysilane (150 mmole) was heated to 65° C., and the Grignard reagent was added dropwise thereto. Further, the solution was stirred at the same temperature for 2 hours, and after left standing for cooling, the reaction mixture was filtered. The solvent was distilled off, and then trans-1-pentyl-4-(trans-4-trimethoxysilylmethyl-cyclohexyl)cyclohexane (65 mmole) was obtained by distillation under reduced pressure.

出典